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Univariate analysis
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Multivariate analysis model 3 (with both BATM and BTSM)
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p
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HR
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95% CI
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p
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HR
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95% CI
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Age (<50 years vs. ≥ 50 years)
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0.055
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1.746
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0.987–3.088
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0.741
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0.843
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0.305–2.326
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Molecular subtype (LuA-like vs. LuB-like vs. TNBC vs. HER2 Lu-like vs. HER2 nonLu like)
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0.03*
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1.213
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1.018–1.444
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0.185
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1.351
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0.866–2.107
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Grading (G1 vs. G2 vs. G3)
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0.003*
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1.763
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1.056–2.945
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0.405
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1.403
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0.633–3.110
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Tumor foci (unifocal vs. multifocal and multicentric)
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0.889
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0.971
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0.642–1.469
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n.i.
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n.i.
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n.i.
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Tumor size (pT1 vs. pT2 vs. pT3 vs. pT4)
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5.573E−13*
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2.064
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1.695–2.513
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0.001*
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1.827
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1.269–2.631
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Axillary lymph node status (pN0 vs. pN1 vs.pN2)
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0.002*
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1.859
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1.256–2.749
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0.285
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1.650
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0.659–4.131
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ER status (ER− vs. ER+)
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0.026*
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0.589
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0.369–0.940
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0.604
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0.718
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0.205–2.515
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PR status (PR− vs. PR+)
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0.088
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0.697
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0.461–1.054
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n.i.
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n.i.
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n.i.
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HER2 status (HER2− vs. HER2+)
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0.079
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1.667
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0.942–2.952
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n.i.
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n.i.
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n.i.
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Expression of ki-67 (ki-67 ≤ 14% vs. ki-67>14%)
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0.891
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1.040
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0.588–1.840
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n.i.
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n.i.
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n.i.
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BATMs (low vs. high)
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0.001*
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2.483
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1.474–4.182
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0.004*
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4.464
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1.624–12.269
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BTSMs (low vs. high)
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0.025*
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2.445
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1.117–5.354
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0.737
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0.813
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0.243–2.721
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- Multivariate analysis model 3 was performed with both BATMs and BTSMs, to determine if BATMs, BTSM or both were independently associated with OS when both subtypes of macrophages were considered. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, LuA-like luminal A-like, LuB-like luminal B-like, TNBC triple-negative breast cancer, HER2 Lu-like HER2 amplified luminal-like, HER2 nonLu like HER2 amplified non luminal-like, BATMs breast adipose tissue macrophages, BTSMs breast tumor-stroma macrophages, HR hazard ratio, CI confidence interval, n.i not included in multivariate model as p > 0.05 in univariate analysis; *significant (p value < 0.05)
