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Body size measurement
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p-mTOR overexpressed cases vs controls
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p-mTOR negative/low cases vs controls
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P-heterogeneity
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OR (95% CI)
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OR (95% CI)
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|---|
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BMI, kg/m2
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No. of cases/no. of controls
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189/1973
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522/1973
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< 25
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1.00 [reference]
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1.00 [reference]
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25–29.99
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1.22 (0.75–1.97)
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1.02 (0.77–1.35)
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30–34.99
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1.52 (0.92–2.47)
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1.11 (0.83–4.19)
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≥ 35
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1.31 (0.80–2.13)
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0.70 (0.52–0.95)
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0.011
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P-trend
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0.31
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0.017
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WC
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No. of cases/no. of controls
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187/1955
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512/1955
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Q1
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1.00 [reference]
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1.00 [reference]
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Q2
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1.67 (0.74–2.96)
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1.10 (0.81–1.50)
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Q3
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2.52 (1.46–4.34)
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1.24 (0.91–1.67)
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Q4
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1.99 (1.12–3.50)
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0.94 (0.69–1.30)
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0.27
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P-trend
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0.029
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0.64
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WHR
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No. of cases/no. of controls
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187/1955
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512/1955
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Q1
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1.00 [reference]
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1.00 [reference]
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Q2
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1.21 (0.71–2.06)
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1.30 (0.96–1.77)
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Q3
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1.82 (1.11–2.98)
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1.32 (0.97–1.80)
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Q4
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1.81 (1.11–2.98)
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1.34 (0.98–1.83)
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0.48
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P-trend
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0.009
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0.10
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- Abbreviations: BMI body mass index, OR odds ratio, Q quartile, WC waist circumference, WHR waist-to-hip ratio
- Models adjusted for age, race, family history of breast cancer, menopausal status, age of menarche, parity, history of breastfeeding, oral contraceptive use, and history of diabetes
- Waist circumference (WC) quartile cutoffs: 83.7, 94.7, and 107.4 inches
- Waist-to-hip ratio (WHR) quartile cutoffs: 0.804, 0.855, and 0.911
- P-heterogeneity: tests for differences in the associations of body fatness measurements between p-mTOR overexpressed tumors and p-mTOR negative/low tumors
