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Table 4 Odds ratios of breast cancer risk in relation to p-mTOR expression associated with body composition measurements

From: Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women

Body composition measurement p-mTOR overexpressed cases vs controls p-mTOR negative/low cases vs controls P-heterogeneity
OR (95% CI) OR (95% CI)
Percent body fat
No. of cases/no. of controls 179/1884 495/1884  
 Q1 1.00 [reference] 1.00 [reference]  
 Q2 1.26 (0.74–2.14) 1.29 (0.95–1.74)  
 Q3 1.55 (0.93–2.58) 0.98 (0.72–1.33)  
 Q4 1.31 (0.77–2.22) 0.71 (0.51–0.99) 0.001
P-trend 0.27 0.015  
Fat mass index
 No. of cases/no. of controls 179/1859 494/1859  
 Q1 1.00 [reference] 1.00 [reference]  
 Q2 1.22 (0.72–2.08) 1.39 (1.03–1.88)  
 Q3 1.34 (0.79–2.26) 1.08 (0.79–1.49)  
 Q4 1.42 (0.84–2.39) 0.77 (0.55–1.07) 0.001
P-trend 0.21 0.008  
  1. Abbreviations: OR odds ratio, Q quartile
  2. Models adjusted for age, race, family history of breast cancer, menopausal status, age of menarche, parity, history of breastfeeding, oral contraceptive use, and history of diabetes
  3. Percent body fat quartile cutoffs: 32.7%, 39.7%, and 45.3%
  4. Fat mass index cutoffs: 8.04, 11.67, and 15.63 kg/m2